Advances in Nutritional Research by S. Harvey Mudd (auth.), Harold H. Draper (eds.)

By S. Harvey Mudd (auth.), Harold H. Draper (eds.)

Volume four of Advances in dietary learn displays the elevated significance that lately has been connected to foodstuff in lots of fields of scientific drugs. This heightened curiosity in foodstuff stems from the demonstration that the consumption of particular meals could have far-reaching effects, not just for regular metabolism, but additionally for metabolic techniques affecting medical or subclinical affliction. Conversely, many sickness states were proven to have formerly unrecognized results on nutrient functionality and metabolism. as well as subject matters of visible relevance to human scientific meals, this quantity comprises chapters facing the foodstuff of cells grown in tradition and of species that can supply insights into dietary issues of guy. To­ gether with its predecessors, quantity four offers graduate scholars and estab­ lished investigators with authoritative bills of the prestige of analysis on quite a number subject matters of present curiosity in experimental and medical nutrients. vii Contents bankruptcy 1. Vitamin-Responsive Genetic Abnormalities .......... . S. Harvey Mudd 1. Introduction.............................................. 1 2. ancient viewpoint ...................................... 2 three. Genetic Abnormalities at the moment recognized to Be nutrition Responsive. three four. Mechanisms Underlying diet Responsiveness. . . . . . . . . . . . . . . . 7 4.1. Defects within the Processing of a diet sooner than Its interplay in Cofactor shape with a selected Apoenzyme ........ 7 4.2. Defects particularly Apoenzymes that engage with the Cofactor types of supplements. . . . . . . . . . . . . . . . . . sixteen . . . . . .

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J. Med. 268:333. Frimpter, G. , Andelman, R. , and George, W. -dependency syndromes. New horizons in nutrition, Am. J. Clin. Nutr. 22:794. , 1965, Pyridoxine-responsive anaemias, Br. J. Haematol. 11:86. Gibbs, D. , and Watts, R. W. , 1970, The action of pyridoxine in primary hyperoxaluria, Clin. Sci. 38:277. , and Hitzig, W. , 1975, Vitamin B12 transport in blood. I. Congenital deficiency of transcobalamin II, Blood 45:71. , Storrs, C. , Bau, D. C. , Peters, T. , and Hughes, E. , 1970, Localization of enzyme defect in propionicacidemia, Lancet 1:1140.

Mudd, S. , Finkelstein, J. , 1964, Homocystinuria: An enzymatic defect, Science 143: 1443. Mudd, S. , Levy, H. , and Abeles, R. , 1969, A derangement in B'2 metabolism leading to homocystinemia, cystathioninemia, and methyl malonic aciduria, Biochem. Biophys. Res. Commun. 35: 121. Mudd, S. , Uhlendorf, B. , Hinds, K. , and Levy, H. , 1970a, Deranged B'2 metabolism: Studies of fibroblasts grown in tissue culture, Biochem. Med. 4:215. Mudd, S. , Edwards, W. , Loeb, P. , Brown, M. , 1970b, Homocystinuria due to cystathionine synthase deficiency: The effect of pyridoxine, J.

Dis. Child. 42:467. Cohen, P. , Sturman, J. , and Gaull, G. , 1973, High pyridoxine diet in the rat: Possible implications for megavitamin therapy, J. Nutr. 103:143. Danner, D. , Davidson, E. , and Elsas, L. J. II, 1975, Thiamine increases the specific activity of human liver branched chain a-ketoacid dehydrogenase, Nature 254:529. Danner, D. , Wheeler, F. , Lemmon, S. , and Elsas, L. J. II, 1978, In vivo and in vitro response of human branched chain a-ketoacid dehydrogenase to thiamine and thiamine pyrophosphate, Pediatr.

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