Advances in Nutrition and Cancer 2 by Peter Greenwald (auth.), Vincenzo Zappia, Fulvio Della

By Peter Greenwald (auth.), Vincenzo Zappia, Fulvio Della Ragione, Alfonso Barbarisi, Gian Luigi Russo, Rossano Dello Iacovo (eds.)

This quantity comprises contributions awarded on the moment foreign Sym­ posium on nutrients and melanoma, held in Naples, Italy, in October 1998 on the nationwide Tumor Institute "Fondazione Pascale." throughout the convention, specialists from varied disciplines mentioned pivotal and well timed topics at the interactions among human meals and the advance of malignancies. evaluating the topics of this assembly with these mentioned on the First Sympo­ sium in 1992, the foremost clinical developments definitely derive from the large use of molecular ways to accomplish examine in nutrients. in addition, the basic statement of R. Doll and R. Peto (1981), which recommended that at the very least 35% of all cancers (with huge alterations between assorted tumors) can be avoided by means of nutritional regimens, has been definitively proven by way of epidemiological reports. nonetheless, the relationships among nutrition and melanoma are fairly complex and complicated; it really is tough, and whilst now not methodologically right, to minimize them to basic phrases. Metabolic and hormonal components, contaminants and organic brokers, and deficiency of particular protecting foodstuff are all items of an identical puzzle.

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3. CONCLUSIONS EPIC represents the largest multicentre molecular epidemiology study ever planned and carried out in Italy. The successful enrollment phase of EPIC-Italy creates a unique opportunity for co-operation between epidemiologists and laboratory scientists in order to test emerging hypotheses in samples obtained from a large population of well-characterised subjects followed over a long period of time. Cancer incidence/mortality will be related to reported dietary habits and biochemical markers of food consumption and individual susceptibility, in order to test the role of diet-related exposures in the aetiology of cancer and its interaction with other environmental or genetic determinants.

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Cancer. 30A:207-220, 1994. 10. Riboli, E. and Kaaks, R The EPIC Project: rationale and study design, Int. 1. Epidemio\' 26 (Supp!. 1):S6-S14,1997. 11. , and Young, 1. (eds) Cancer Incidence In Five Continents, IARe Scientific Publications, VII (143), Lyon (1997). 12. , and Berrino, E Relative validity and reproducibility of a food-frequency dietary questionnaire for use in the Italian EPIC centres, Int. 1. Epidemio\' 26 (Supp!. 1):SI52-S160, 1997. 13. , and Turrini, A Banca Dati di Composizione degli Alimenti per Studi Epidemiologici in Italia, lEO, Milan 1998.

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