Advances in Down Syndrome Research by Y. Kazuki, T. C. Schulz, T. Shinohara, M. Kadota (auth.),

By Y. Kazuki, T. C. Schulz, T. Shinohara, M. Kadota (auth.), Prof. Dr. G. Lubec (eds.)

"Advances in Down Syndrome learn” represents up to date learn in numerous components of Down Syndrome (DS). a brand new promising animal version of DS is mentioned and this opens new possibilities to review pathomechanisms and pharmacological ways because it is greater than tough to hold out reports in people and the medical positive aspects are hugely variable. when it comes to biology, phone cycle and stem mobile stories and by way of biochemistry, relevance of stories on a particular protein kinase, channels, transporters, superoxide dismutase, antioxidant procedure, chromosome meeting issue and different very important organic constructions are supplied. And back, the gene dosage speculation is addressed and even if nearly all of chromosome 21 gene items is unchanged in fetal DS mind, a number of particular chromosome 21 encoded buildings together with transcription elements are certainly overexpressed even though findings in fetal DS are diverse from these in grownup DS mind while Alzheimer-like neuropathology supervenes.

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Gene (in press) Graef lA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW, Crabtree GR (1999) L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature 401: 703-708 Granholm AC, Sanders LA, Crnic LS (2000) Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome. ExpNeurol 161: 647-663 Hassold TJ, Jacobs PA (1984) Trisomy in man. Annu Rev Genet 18: 69-97 Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon 0, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand El, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (2000) The DNA sequence of human chromosome 21.

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Annu Rev Genet 18: 69-97 Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon 0, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand El, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (2000) The DNA sequence of human chromosome 21.

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