9th Report on Carcinogens: Revised January 2001

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Additional info for 9th Report on Carcinogens: Revised January 2001

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PROPERTIES 4-Aminobiphenyl occurs as colorless crystals which turn purple upon oxidation. It has a floral odor. It is slightly soluble in cold water and soluble in hot water, non-polar solvents, and lipids. When heated to decomposition, it emits toxic fumes of nitrogen oxides (NOx). USE 4-Aminobiphenyl presently has no commercial use in the United States, although it was formerly used as a rubber antioxidant and a dye intermediate (HSDB, 1997). The compound has also been used as a research chemical and as a reagent for detecting sulfates (Merck, 1983; Sittig, 1985).

5 million workers are estimated to have some potential exposure to asbestos. , asbestos insulation workers, brake repair and maintenance workers, building demolition workers, and asbestos abatement workers. The National Occupational Exposure Survey (NOES) (1981-1983) estimated that 153,937 total workers, including 7,603 women, were potentially exposed to asbestos (NIOSH, 1984). The total estimate was based on actual observations of asbestos (41%) and its use in tradename products (59%). The NOES estimated that 30,594 total workers, including 3,410 women, potentially were exposed to chrysotile.

When administered in the diet, the compound induced carcinoma of the urinary bladder in dogs. When administered by subcutaneous injection, 4-aminobiphenyl induced mammary gland and intestinal tumors in rats and hepatomas in newborn mice of both sexes. PROPERTIES 4-Aminobiphenyl occurs as colorless crystals which turn purple upon oxidation. It has a floral odor. It is slightly soluble in cold water and soluble in hot water, non-polar solvents, and lipids. When heated to decomposition, it emits toxic fumes of nitrogen oxides (NOx).

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